Rabbit Polyclonal Antibody to SPAM1

包装: 1G|100G|500G|1KG|100KG

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别名:Hyaluronidase PH-20, Hyal-PH20, Hyaluronoglucosaminidase PH-20, Sperm adhesion molecule 1, Sperm surface protein PH-20, SPAM1, HYAL3, PH20
应用:WB
反应种属:Human
规格：50μl/100μl

Description
Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

Description

Hyaluronidase degrades hyaluronic acid, a major structural
proteoglycan found in extracellular matrices and basement
membranes. Six members of the hyaluronidase family are clustered
into two tightly linked groups on chromosome 3p21.3 and 7q31.3.
This gene was previously referred to as HYAL1 and HYA1 and has
since been assigned the official symbol SPAM1; another family
member on chromosome 3p21.3 has been assigned HYAL1. This gene
encodes a GPI-anchored enzyme located on the human sperm surface
and inner acrosomal membrane. This multifunctional protein is a
hyaluronidase that enables sperm to penetrate through the
hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a
receptor that plays a role in hyaluronic acid induced cell
signaling, and a receptor that is involved in sperm-zona pellucida
adhesion. Abnormal expression of this gene in tumors has implicated
this protein in degradation of basement membranes leading to tumor
invasion and metastasis. Multiple transcript variants encoding
different isoforms have been found for this gene. [provided by
RefSeq].

Specification
Aliases	Hyaluronidase PH-20, Hyal-PH20, Hyaluronoglucosaminidase PH-20, Sperm adhesion molecule 1, Sperm surface protein PH-20, SPAM1, HYAL3, PH20
Entrez GeneID	6677
Swissprot	P38567
WB Predicted band size	57.8kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This SPAM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 429-457 amino acids from the C-terminal region of human SPAM1.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.