Rabbit Polyclonal Antibody to SPATA19

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别名:CT132; SPAS1; spergen1
应用:IHC
反应种属:Human
规格：50μl/100μl

Description
SPATA19(spermatogenesis associated 19), also known as spergen1 (spermatogenic cell-specific gene 1 protein), CT132 or SPAS1, is a 167 amino acid mitochondrial outer membrane protein suggested to function in spermiogenesis. Expressed specifically in testis, SPATA19 is encoded by a gene that maps to human chromosome 11, which comprises approximately 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxiatelangiectasia. The blood disorders Sickle cell anemia and thalassemia are caused by HBB gene mutations, while Wilms’ tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11-encoded genes.

Description

SPATA19(spermatogenesis associated 19), also known as spergen1 (spermatogenic cell-specific gene 1 protein), CT132 or SPAS1, is a 167 amino acid mitochondrial outer membrane protein suggested to function in spermiogenesis. Expressed specifically in testis, SPATA19 is encoded by a gene that maps to human chromosome 11, which comprises approximately 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxiatelangiectasia. The blood disorders Sickle cell anemia and thalassemia are caused by HBB gene mutations, while Wilms’ tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11-encoded genes.

Specification
Aliases	CT132; SPAS1; spergen1
Swissprot	Q7Z5L4
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Fusion protein of human SPATA19
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Application
IHC	1/25-1/100
ELISA	1/5000-1/10000

	The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P07693(SPATA19 Antibody) at dilution 1/20. (Original magnification: ×200)
	The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P07693(SPATA19 Antibody) at dilution 1/20. (Original magnification: ×200)