中文 
别名:Signal transducer and activator of transcription 3, Acute-phase response factor, STAT3, APRF应用:WB,ICC
反应种属:Human, Mouse, Rat
规格：50μl/100μl
| Description |
|---|
| Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute- phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity). |
| Specification | |
|---|---|
| Aliases | Signal transducer and activator of transcription 3, Acute-phase response factor, STAT3, APRF |
| Entrez GeneID | 6774 |
| Swissprot | P40763 |
| WB Predicted band size | 88.1kDa |
| Host/Isotype | Rabbit IgG |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This STAT3(S727) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 710-740 amino acids from the human region of human STAT3(S727). |
| Application | |
|---|---|
| WB | 1/2000 |
| ICC | 1/25 |
 |
Anti-STAT3(S727) Antibody at 1:2000 dilution + NIH/3T3 whole cell lysate
Lysates/proteins at 20 µg per lane. Secondary Predicted band size : 88 kDa Blocking/Dilution buffer: 5% NFDM/TBST. |
 |
Immunofluorescent analysis of 4% paraformaldehyde-fixed, 0. 1% Triton X-100 permeabilized Hela cells labeling STAT3 with P34693 at 1/25 dilution, followed by Dylight® 488-conjugated goat anti-Rabbit IgG secondary antibody at 1/200 dilution (green). Immunofluorescence image showing Nucleus and Weak Cytoplasm staining on Hela cell line. Cytoplasmic actin is detected with Dylight® 554 Phalloidin(red). The nuclear counter stain is DAPI (blue). |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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