Rabbit Polyclonal Antibody to STC2

包装: 1G|100G|500G|1KG|100KG

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别名:Stanniocalcin-2, STC-2, Stanniocalcin-related protein, STC-related protein, STCRP, STC2
应用:WB,IHC
反应种属:Mouse
规格：50μl/100μl

Description
This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers.

Description

This gene encodes a secreted, homodimeric glycoprotein
that is expressed in a wide variety of tissues and may have
autocrine or paracrine functions. The encoded protein has 10 of its
15 cysteine residues conserved among stanniocalcin family members
and is phosphorylated by casein kinase 2 exclusively on its serine
residues. Its C-terminus contains a cluster of histidine residues
which may interact with metal ions. The protein may play a role in
the regulation of renal and intestinal calcium and phosphate
transport, cell metabolism, or cellular calcium/phosphate
homeostasis. Constitutive overexpression of human stanniocalcin 2
in mice resulted in pre- and postnatal growth restriction, reduced
bone and skeletal muscle growth, and organomegaly. Expression of
this gene is induced by estrogen and altered in some breast
cancers.

Specification
Aliases	Stanniocalcin-2, STC-2, Stanniocalcin-related protein, STC-related protein, STCRP, STC2
Entrez GeneID	8614
Swissprot	O76061
WB Predicted band size	33.2kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Mouse
Immunogen	This STC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 273-302 amino acids from the C-terminal region of human STC2.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500

	STC2 Antibody (C-term) (Cat. #P31443) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the STC2 antibody detected the STC2 protein (arrow).
	STC2 Antibody (C-term) (Cat. #P31443)immunohistochemistry analysis in formalin fixed and paraffin embedded human prostate tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of STC2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.