中文 
别名:EC 2.7.11.1; STE20-like kinase MST3; MST-3; Mammalian STE20-like protein kinase 3;应用:WB,IHC
反应种属:Human
规格：50μl/100μl
| Description |
|---|
| Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on ‘Thr-442’ and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve.Schinkmann K., J. Biol. Chem. 272:28695-28703(1997).Zhou T.-H., J. Biol. Chem. 275:2513-2519(2000).Dunham A., Nature 428:522-528(2004). |
| Specification | |
|---|---|
| Aliases | EC 2.7.11.1; STE20-like kinase MST3; MST-3; Mammalian STE20-like protein kinase 3; |
| Entrez GeneID | 8428; |
| Swissprot | Q9Y6E0 |
| WB Predicted band size | 50kDa |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human STK24. |
| Formulation | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Application | |
|---|---|
| WB | 1/500-1/3000 |
| IHC | 1/50-1/100 |
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Western blot analysis of extracts from COLO cells, using STK24 antibody P42589. |
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Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using STK24 antibody P42589. |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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