中文 
别名:Serine/threonine-protein kinase 36 EC 2.7.11.1; Fused homolog STK36;应用:WB,IHC
反应种属:Human
规格：50μl/100μl
| Description |
|---|
| Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function. Essential for construction of the central pair apparatus of motile cilia.Murone M., Nat. Cell Biol. 2:310-312(2000).Nagase T., DNA Res. 6:337-345(1999).Hillier L.W., Nature 434:724-731(2005). |
| Specification | |
|---|---|
| Aliases | Serine/threonine-protein kinase 36 EC 2.7.11.1; Fused homolog STK36; |
| Entrez GeneID | 27148; |
| Swissprot | Q9NRP7 |
| WB Predicted band size | 170kDa |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human STK36. |
| Formulation | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Application | |
|---|---|
| WB | 1/500-1/3000 |
| IHC | 1/50-1/100 |
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Western blot analysis of extracts from K562 cells, using STK36 antibody P42590. |
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Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using STK36 antibody P42590. |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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