Rabbit Polyclonal Antibody to SYN1

包装: 1G|100G|500G|1KG|100KG

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别名:SYNI; SYN1a; SYN1b
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.

Description

This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.

Specification
Aliases	SYNI; SYN1a; SYN1b
Swissprot	P17600
WB Predicted band size	74 kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthetic peptide of human SYN1
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Application
WB	1/500-1/2000
IHC	1/50-1/200
ELISA	1/2000-1/5000

	Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-4: A375 cells, 231 cells, 293T cells, human hepatocellular carcinoma tissue, Primary antibody: P11852(SYN1 Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds
	The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P11852(SYN1 Antibody) at dilution 1/50. (Original magnification: ×200)
	The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using P11852(SYN1 Antibody) at dilution 1/50. (Original magnification: ×200)