Rabbit Polyclonal Antibody to SYN3

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别名:Synapsin-3, Synapsin III, SYN3
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. The protein encoded by this gene shares the synapsin family domain model, with domains A, C, and E exhibiting the highest degree of conservation. The protein contains a unique domain J, located between domains C and E. Based on this gene’s localization to 22q12.3, a possible schizophrenia susceptibility locus, and the established neurobiological roles of the synapsins, this family member may represent a candidate gene for schizophrenia. The TIMP3 gene is located within an intron of this gene and is transcribed in the opposite direction.

Description

This gene is a member of the synapsin gene family.
Synapsins encode neuronal phosphoproteins which associate with the
cytoplasmic surface of synaptic vesicles. Family members are
characterized by common protein domains, and they are implicated in
synaptogenesis and the modulation of neurotransmitter release,
suggesting a potential role in several neuropsychiatric diseases.
The protein encoded by this gene shares the synapsin family domain
model, with domains A, C, and E exhibiting the highest degree of
conservation. The protein contains a unique domain J, located
between domains C and E. Based on this gene’s localization to
22q12.3, a possible schizophrenia susceptibility locus, and the
established neurobiological roles of the synapsins, this family
member may represent a candidate gene for schizophrenia. The TIMP3
gene is located within an intron of this gene and is transcribed in
the opposite direction.

Specification
Aliases	Synapsin-3, Synapsin III, SYN3
Entrez GeneID	8224
Swissprot	O14994
WB Predicted band size	63.3kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This SYN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 363-388 amino acids from the Central region of human SYN3.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500

	SYN3 Antibody (Center) (Cat. #P30713) western blot analysis in NCI-H460 cell line lysates (15ug/lane).This demonstrates the SYN3 antibody detected the SYN3 protein (arrow).
	SYN3 Antibody (Center) (Cat. #P30713) immunohistochemistry analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the SYN3 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.