Rabbit Polyclonal Antibody to TAB1

包装: 1G|100G|500G|1KG|100KG

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别名:3′-Tab1; MAP3K7IP1
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1.

Description

The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1.

Specification
Aliases	3′-Tab1; MAP3K7IP1
Entrez GeneID	10454;
Swissprot	Q15750
WB Predicted band size	55kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Fusion protein corresponding to a region derived from internal residues of human TGF-beta activated kinase 1/MAP3K7 binding protein 1
Formulation	Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Application
WB	1/200-1/1000
IHC	1/100-1/300

	Gel: 6%SDS-PAGE Lysate: 40ug 293T cell Primary antibody: 1/350 dilution Secondary antibody dilution: 1/8000 Exposure time: 20 seconds
	Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue using P42829 at dilution 1/50.