Rabbit Polyclonal Antibody to Tau (Ab-396)

包装: 1G|100G|500G|1KG|100KG

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别名:MAPT; Microtubule-associated protein tau; MTBT1; Neurofibrillary tangle protein; Paired helical filament-tau
应用:WB
反应种属:Human
规格：50μl/100μl

Description
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.Puig B, et al. (2005) Acta Neuropathol (Berl). 110(3):261-268.DeGiorgis JA, et al. (2005) J Proteome Res. 4(2): 306-315.Alonso Adel C, et al. (2004) J Biol Chem. 279(33): 34873-34881.

Description

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.Puig B, et al. (2005) Acta Neuropathol (Berl). 110(3):261-268.DeGiorgis JA, et al. (2005) J Proteome Res. 4(2): 306-315.Alonso Adel C, et al. (2004) J Biol Chem. 279(33): 34873-34881.

Specification
Aliases	MAPT; Microtubule-associated protein tau; MTBT1; Neurofibrillary tangle protein; Paired helical filament-tau
Entrez GeneID	4137;
Swissprot	P10636
WB Predicted band size	78kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized non-phosphopeptide derived from human Tau around the phosphorylation site of Serine 396.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000

	Western blot analysis of extracts from HeLa cells, using Tau (Ab-396) antibody P41695.
	Western blot analysis of extracts from 293 cells (Lane 2), using Tau (Ab-396) antiobdy P41695. The lane on the left is treated with synthesized peptide.