Rabbit Polyclonal Antibody to TBC1D4

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别名:AS160
应用:WB,IHC
反应种属:Human, Mouse
规格：50μl/100μl

Description
TBC1 domain family member 4 (TBC1D4), also designated AS160, can be insulin- and/or AKT1-induced. Insulin-stimulated phosphorylation is required for GLUT4 translocation. TBC1D4 may play a role as a GTPase activating protein for proteins in the Rab family. It is expressed primarily in skeletal muscle and heart, as well as spleen, lymph node and leukocytes. Defects in the TBC1D4 gene may cause atopic dermatitis (AD), sometimes referred to as eczema, an atopic chronic skin disease. The skin of affected individuals reacts to irritants or allergens and becomes red, flaky and itchy. The skin is also more vulnerable to inflammations, and symptoms can grow or disappear over time.

Description

TBC1 domain family member 4 (TBC1D4), also designated AS160, can be insulin- and/or AKT1-induced. Insulin-stimulated phosphorylation is required for GLUT4 translocation. TBC1D4 may play a role as a GTPase activating protein for proteins in the Rab family. It is expressed primarily in skeletal muscle and heart, as well as spleen, lymph node and leukocytes. Defects in the TBC1D4 gene may cause atopic dermatitis (AD), sometimes referred to as eczema, an atopic chronic skin disease. The skin of affected individuals reacts to irritants or allergens and becomes red, flaky and itchy. The skin is also more vulnerable to inflammations, and symptoms can grow or disappear over time.

Specification
Aliases	AS160
Swissprot	O60343
WB Predicted band size	147 kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse
Immunogen	Synthetic peptide of human TBC1D4
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Application
WB	1/500-1/2000
IHC	1/30-1/150
ELISA	1/2000-1/5000

	Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hela cells, hepg2 cells, Primary antibody: P05394(TBC1D4 Antibody) at dilution 1/320, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds
	The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P05394(TBC1D4 Antibody) at dilution 1/40. (Original magnification: ×200)