Rabbit Polyclonal Antibody to TEAD3

包装: 1G|100G|500G|1KG|100KG

现货支持定制

QQ咨询
| 微信咨询

满200元免运费
正品保障提供发票
现货闪电当时发货

别名:Transcriptional enhancer factor TEF-5; TEA domain family member 3; TEAD-3; DTEF-1; TEAD3
应用:WB
反应种属:Human
规格：50μl/100μl

Description
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.Jacquemin P., J. Biol. Chem. 272:12928-12937(1997).Mungall A.J., Nature 425:805-811(2003).Zhao B., Genes Dev. 22:1962-1971(2008).

Description

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.Jacquemin P., J. Biol. Chem. 272:12928-12937(1997).Mungall A.J., Nature 425:805-811(2003).Zhao B., Genes Dev. 22:1962-1971(2008).

Specification
Aliases	Transcriptional enhancer factor TEF-5; TEA domain family member 3; TEAD-3; DTEF-1; TEAD3
Entrez GeneID	7005;
Swissprot	Q99594
WB Predicted band size	49kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized peptide derived from internal of human TEAD3.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.