Rabbit Polyclonal Antibody to TERF2

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别名:Telomeric repeat-binding factor 2, TTAGGG repeat-binding factor 2, Telomeric DNA-binding protein, TERF2, TRBF2, TRF2
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic.

Description

This gene encodes a telomere specific protein, TERF2,
which is a component of the telomere nucleoprotein complex. This
protein is present at telomeres in metaphase of the cell cycle, is
a second negative regulator of telomere length and plays a key role
in the protective activity of telomeres. While having similar
telomere binding activity and domain organization, TERF2 differs
from TERF1 in that its N terminus is basic rather than acidic.

Specification
Aliases	Telomeric repeat-binding factor 2, TTAGGG repeat-binding factor 2, Telomeric DNA-binding protein, TERF2, TRBF2, TRF2
Entrez GeneID	7014
Swissprot	Q15554
WB Predicted band size	59.6kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This TERF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-337 amino acids from the Central region of human TERF2.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500

	TERF2 Antibody (Center) (Cat. #P31353) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the TERF2 antibody detected the TERF2 protein (arrow).
	TERF2 Antibody (Center) (P31353)immunohistochemistry analysis in formalin fixed and paraffin embedded human colon tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TERF2 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.