中文 
别名:THO complex subunit 5 homolog; NF2/meningioma region protein pK1.3; Placental protein 39.2; THOC5; C22orf19应用:WB,IHC
反应种属:Human
规格：50μl/100μl
| Description |
|---|
| Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5′ end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi’s sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5′ region of target genes; probaly mediates association of the TREX and CFIm complexes. Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development.Xie Y.G., Hum. Mol. Genet. 2:1361-1368(1993).Nagase T., DNA Res. 6:63-70(1999).Collins J.E., Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004) |
| Specification | |
|---|---|
| Aliases | THO complex subunit 5 homolog; NF2/meningioma region protein pK1.3; Placental protein 39.2; THOC5; C22orf19 |
| Entrez GeneID | 8563; |
| Swissprot | Q13769 |
| WB Predicted band size | 78kDa |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human THOC5. |
| Formulation | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Application | |
|---|---|
| WB | 1/500-1/3000 |
| IHC | 1/50-1/100 |
 |
Western blot analysis of extracts from JK cells and HepG2 cells, using THOC5 antiobdy P42658. |
 |
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using THOC5 antibody P42658. |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
暂无评论
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
发表回复