Rabbit Polyclonal Antibody to Thrombomodulin

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别名:CD141; Fetomodulin; THBD; THRM; thrombomodulin; TM
应用:WB,IHC,ICC,IP
反应种属:Human
规格：50μl/100μl

Description
Thrombomodulin (TM), also called CD141, is a type I membrane receptor that is specific to endothelial cells. TM has a cysteine-rich extracellular domain with six EGF-like regions. It forms a complex with Thrombin, which activates Protein C to generate activated Protein C (APC), an anticoagulant enzyme. APC together with Protein S inhibits coagulation by inactivating Factors Va and VIIIa. Deletion of the TM gene results in embryonic lethality in mice.

Description

Thrombomodulin (TM), also called CD141, is a type I membrane receptor that is specific to endothelial cells. TM has a cysteine-rich extracellular domain with six EGF-like regions. It forms a complex with Thrombin, which activates Protein C to generate activated Protein C (APC), an anticoagulant enzyme. APC together with Protein S inhibits coagulation by inactivating Factors Va and VIIIa. Deletion of the TM gene results in embryonic lethality in mice.

Specification
Aliases	CD141; Fetomodulin; THBD; THRM; thrombomodulin; TM
Entrez GeneID	7056
Swissprot	P07204
WB Predicted band size	Calculated MW: 60 kDa; Observed MW: 60 kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	A synthesized peptide derived from human Thrombomodulin
Formulation	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
IP	1/20
WB	1/500-1/1000
IHC	1/50-1/100
ICC	1/50-1/200

	Western blot analysis of Thrombomodulin in Human placenta lysates using Thrombomodulin antibody.
	Immunohistochemistry analysis of paraffin-embedded Human bladder using Thrombomodulin antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.