中文 
别名:kinase TLK1; PKU-beta; tousled-like kinase 1;应用:WB
反应种属:Human,Mouse,Rat
规格：50μl/100μl
| Description |
|---|
| Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at ‘Ser-10’.Yamakawa A., Gene 202:193-201(1997).Sillje H.H.W., EMBO J. 18:5691-5702(1999).Cabaniols J.-P., Mol. Biol. Cell 10:4033-4041(1999). |
| Specification | |
|---|---|
| Aliases | kinase TLK1; PKU-beta; tousled-like kinase 1; |
| Entrez GeneID | 9874; |
| Swissprot | Q9UKI8 |
| WB Predicted band size | 87kDa |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from internal of human TLK1. |
| Formulation | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Application | |
|---|---|
| WB | 1/500-1/3000 |
 |
Western blot analysis of extracts from rat brain cells and NIH/3T3 cells, using TLK1 antibody P42734. |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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