Rabbit Polyclonal Antibody to TMEM43

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别名:Transmembrane protein 43, Protein LUMA, TMEM43
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
This gene belongs to the TMEM43 family. Defects in this gene are the cause of familial arrhythmogenic right ventricular dysplasia type 5 (ARVD5), also known as arrhythmogenic right ventricular cardiomyopathy type 5 (ARVC5). Arrhythmogenic right ventricular dysplasia is an inherited disorder, often involving both ventricles, and is characterized by ventricular tachycardia, heart failure, sudden cardiac death, and fibrofatty replacement of cardiomyocytes. This gene contains a response element for PPAR gamma (an adipogenic transcription factor), which may explain the fibrofatty replacement of the myocardium, a characteristic pathological finding in ARVC.

Description

This gene belongs to the TMEM43 family. Defects in this
gene are the cause of familial arrhythmogenic right ventricular
dysplasia type 5 (ARVD5), also known as arrhythmogenic right
ventricular cardiomyopathy type 5 (ARVC5). Arrhythmogenic right
ventricular dysplasia is an inherited disorder, often involving
both ventricles, and is characterized by ventricular tachycardia,
heart failure, sudden cardiac death, and fibrofatty replacement of
cardiomyocytes. This gene contains a response element for PPAR
gamma (an adipogenic transcription factor), which may explain the
fibrofatty replacement of the myocardium, a characteristic
pathological finding in ARVC.

Specification
Aliases	Transmembrane protein 43, Protein LUMA, TMEM43
Entrez GeneID	79188
Swissprot	Q9BTV4
WB Predicted band size	44.9kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This TMEM43 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 195-223 amino acids from the Central region of human TMEM43.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500

	TMEM43 Antibody (Center) (Cat. #P31119) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the TMEM43 antibody detected the TMEM43 protein (arrow).
	TMEM43 Antibody (Center) (Cat. #P31119)immunohistochemistry analysis in formalin fixed and paraffin embedded human esophageal carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TMEM43 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.