Rabbit Polyclonal Antibody to TNFRSF11B

包装: 1G|100G|500G|1KG|100KG

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别名:OPG; TR1; OCIF; PDB5
应用:IHC
反应种属:Human, Mouse, Rat
规格：50μl/100μl

Description
The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.

Description

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.

Specification
Aliases	OPG; TR1; OCIF; PDB5
Swissprot	O00300
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse, Rat
Immunogen	Fusion protein of human TNFRSF11B
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Application
IHC	1/50-1/200
ELISA	1/5000-1/10000

	The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P07507(TNFRSF11B Antibody) at dilution 1/75. (Original magnification: ×200)
	The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P07507(TNFRSF11B Antibody) at dilution 1/75. (Original magnification: ×200)