Rabbit Polyclonal Antibody to TNNI2 (N-term)

包装: 1G|100G|500G|1KG|100KG

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别名:Troponin I, fast skeletal muscle, Troponin I, fast-twitch isoform, TNNI2
应用:WB
反应种属:Human
规格：50μl/100μl

Description
This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq].

Description

This gene encodes a fast-twitch skeletal muscle protein, a
member of the troponin I gene family, and a component of the
troponin complex including troponin T, troponin C and troponin I
subunits. The troponin complex, along with tropomyosin, is
responsible for the calcium-dependent regulation of striated muscle
contraction. Mouse studies show that this component is also present
in vascular smooth muscle and may play a role in regulation of
smooth muscle function. In addition to muscle tissues, this protein
is found in corneal epithelium, cartilage where it is an inhibitor
of angiogenesis to inhibit tumor growth and metastasis, and mammary
gland where it functions as a co-activator of estrogen
receptor-related receptor alpha. This protein also suppresses tumor
growth in human ovarian carcinoma. Mutations in this gene cause
myopathy and distal arthrogryposis type 2B. Alternatively spliced
transcript variants have been found for this gene. [provided by
RefSeq].

Specification
Aliases	Troponin I, fast skeletal muscle, Troponin I, fast-twitch isoform, TNNI2
Entrez GeneID	7136
Swissprot	P48788
WB Predicted band size	21.3kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This TNNI2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human TNNI2.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.