Rabbit Polyclonal Antibody to TP53INP1

包装: 1G|100G|500G|1KG|100KG

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别名:Tumor protein p53-inducible nuclear protein 1; p53-dependent damage-inducible nuclear protein 1; p53DINP1; Stress-induced protein; TP53INP1
应用:WB
反应种属:Human
规格：50μl/100μl

Description
Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on ‘Ser-46’ and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.Okamura S., Mol. Cell 8:85-94(2001).Tomasini R., Eur. J. Cell Biol. 81:294-301(2002).Tomasini R., J. Biol. Chem. 278:37722-37729(2003).

Description

Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on ‘Ser-46’ and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.Okamura S., Mol. Cell 8:85-94(2001).Tomasini R., Eur. J. Cell Biol. 81:294-301(2002).Tomasini R., J. Biol. Chem. 278:37722-37729(2003).

Specification
Aliases	Tumor protein p53-inducible nuclear protein 1; p53-dependent damage-inducible nuclear protein 1; p53DINP1; Stress-induced protein; TP53INP1
Entrez GeneID	94241;
Swissprot	Q96A56
WB Predicted band size	27kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized peptide derived from C-terminal of human TP53INP1.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.