Rabbit Polyclonal Antibody to TPM4 (N-term)

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别名:Tropomyosin alpha-4 chain, TM30p1, Tropomyosin-4, TPM4
应用:WB,IHC,FCM
反应种属:Human
规格：50μl/100μl

Description
This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

Description

This gene encodes a member of the tropomyosin family of
actin-binding proteins involved in the contractile system of
striated and smooth muscles and the cytoskeleton of non-muscle
cells. Tropomyosins are dimers of coiled-coil proteins that
polymerize end-to-end along the major groove in most actin
filaments. They provide stability to the filaments and regulate
access of other actin-binding proteins. In muscle cells, they
regulate muscle contraction by controlling the binding of myosin
heads to the actin filament. Multiple transcript variants encoding
different isoforms have been found for this gene. [provided by
RefSeq].

Specification
Aliases	Tropomyosin alpha-4 chain, TM30p1, Tropomyosin-4, TPM4
Entrez GeneID	7171
Swissprot	P67936
WB Predicted band size	28.5kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This TPM4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-54 amino acids from the N-terminal region of human TPM4.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100
FCM	1/10-1/50

	TPM4 Antibody (N-term) (Cat. #P31149) western blot analysis in U251,A549,Jurkat cell line lysates (35ug/lane).This demonstrates the TPM4 antibody detected the TPM4 protein (arrow).
	TPM4 Antibody (N-term) (Cat. #P31149) flow cytometric analysis of U251 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
	Formalin-fixed and paraffin-embedded H.breast tissue reacted with TPM4 Antibody (N-term) (Cat#P31149).
	Formalin-fixed and paraffin-embedded H.skeletal muscle tissue reacted with TPM4 Antibody (N-term) (Cat#P31149).