Rabbit Polyclonal Antibody to TPSD1

包装: 1G|100G|500G|1KG|100KG

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别名:Tryptase delta, Delta-tryptase, HmMCP-3-like tryptase III, Mast cell mMCP-7-like, Tryptase-3, TPSD1
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3′ UTR and contain tandem repeat sequences at the 5′ flank and 3′ UTR which are thought to play a role in regulation of the mRNA stability. Although this gene may be an exception, most of the tryptase genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. TPSD1 was once considered to be a pseudogene, although it is now believed to be a functional gene that encodes a protein.

Description

Tryptases comprise a family of trypsin-like serine
proteases, the peptidase family S1. Tryptases are enzymatically
active only as heparin-stabilized tetramers, and they are resistant
to all known endogenous proteinase inhibitors. Several tryptase
genes are clustered on chromosome 16p13.3. These genes are
characterized by several distinct features. They have a highly
conserved 3′ UTR and contain tandem repeat sequences at the 5′
flank and 3′ UTR which are thought to play a role in regulation of
the mRNA stability. Although this gene may be an exception, most of
the tryptase genes have an intron immediately upstream of the
initiator Met codon, which separates the site of transcription
initiation from protein coding sequence. This feature is
characteristic of tryptases but is unusual in other genes.
Tryptases have been implicated as mediators in the pathogenesis of
asthma and other allergic and inflammatory disorders. TPSD1 was
once considered to be a pseudogene, although it is now believed to
be a functional gene that encodes a protein.

Specification
Aliases	Tryptase delta, Delta-tryptase, HmMCP-3-like tryptase III, Mast cell mMCP-7-like, Tryptase-3, TPSD1
Entrez GeneID	23430
Swissprot	Q9BZJ3
WB Predicted band size	26.6kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This TPSD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 164-193 amino acids from the C-terminal region of human TPSD1.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000-1/2000
IHC	1/100-1/500

	TPSD1 Antibody (C-term) (Cat. #P30796) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the TPSD1 antibody detected the TPSD1 protein (arrow).
	TPSD1 antibody (C-term) (Cat. #P30796) immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the TPSD1 antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.