Rabbit Polyclonal Antibody to TRADD

包装: 1G|100G|500G|1KG|100KG

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别名:Tumor necrosis factor receptor type 1-associated DEATH domain protein, TNFR1-associated DEATH domain protein, TNFRSF1A-associated via death domain, TRADD
应用:WB,IHC,ICC,FCM
反应种属:Human
规格：50μl/100μl

Description
The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq].

Description

The protein encoded by this gene is a death domain
containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and
mediates programmed cell death signaling and NF-kappaB activation.
This protein binds adaptor protein TRAF2, reduces the recruitment
of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus
suppresses TRAF2 mediated apoptosis. This protein can also interact
with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is
involved in the Fas-induced cell death pathway. [provided by
RefSeq].

Specification
Aliases	Tumor necrosis factor receptor type 1-associated DEATH domain protein, TNFR1-associated DEATH domain protein, TNFRSF1A-associated via death domain, TRADD
Entrez GeneID	8717
Swissprot	Q15628
WB Predicted band size	34.2kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This TRADD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 126-151 amino acids from the Central region of human TRADD.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500
ICC	1/10-1/50
FCM	1/10-1/50

	TRADD Antibody (Center) (Cat. #P31021) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the TRADD antibody detected the TRADD protein (arrow).
	Confocal immunofluorescent analysis of TRADD Antibody (Center)(Cat#P31021) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). Actin filaments have been labeled with Alexa Fluor555 phalloidin (red). DAPI was used to stain the cell nuclear (blue).
	TRADD Antibody (Center) (Cat. #P31021) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
	TRADD Antibody (Center) (Cat. #P31021)immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TRADD Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.