中文 
别名:TRKA; TRK; NTRK1; p140-TrkA;应用:IHC
反应种属:Human,Mouse
规格：50μl/100μl
| Description |
|---|
| Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.Martin-Zanca D., Mol. Cell. Biol. 9:24-33(1989)Shelton D.L., J. Neurosci. 15:477-491(1995)The MGC Project Team, Genome Res. 14:2121-2127(2004) |
| Specification | |
|---|---|
| Aliases | TRKA; TRK; NTRK1; p140-TrkA; |
| Entrez GeneID | 4914; |
| Swissprot | P04629 |
| WB Predicted band size | 87kDa |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Peptide sequence around phosphorylation site of tyrosine 757 (E-V-Y(p)-A-I) derived from Human Trk A. |
| Formulation | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Application | |
|---|---|
| IHC | 1/50-1/100 |
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Immunohistochemical analysis of paraffin-embedded human brain tissue using Trk A (Phospho-Tyr757) antibody P40458 (left)or the same antibody preincubated with blocking peptide (right). |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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