Rabbit Polyclonal Antibody to UBE1L

包装: 1G|100G|500G|1KG|100KG

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别名:D8; UBE2; ubiquitin-activating enzyme E1 homolog; ubiquitin-activating enzyme E1-like; ubiquitin-activating enzyme E1-related protein
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
Activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Catalyzes the ISGylation of influenza A virus NS1 protein.Sutisak Kitareewan, PNAS, Mar 2002; 99: 3806. Keun Il Kim, Mol. Cell. Biol., Jan 2006; 26: 472 – 479. Ian Pitha-Rowe, Cancer Res., Nov 2004; 64: 8109 – 8115.

Description

Activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Catalyzes the ISGylation of influenza A virus NS1 protein.Sutisak Kitareewan, PNAS, Mar 2002; 99: 3806. Keun Il Kim, Mol. Cell. Biol., Jan 2006; 26: 472 – 479. Ian Pitha-Rowe, Cancer Res., Nov 2004; 64: 8109 – 8115.

Specification
Aliases	D8; UBE2; ubiquitin-activating enzyme E1 homolog; ubiquitin-activating enzyme E1-like; ubiquitin-activating enzyme E1-related protein
Entrez GeneID	7318;
Swissprot	P41226
WB Predicted band size	112kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized peptide derived from C-terminal of human UBE1L.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000
IHC	1/50-1/100

	Western blot analysis of extracts from HeLa cells, using UBE1L antibody P41847.
	Western blot analysis of extracts from JK cells (Lane 2), using UBE1L antiobdy P41847. The lane on the left is treated with synthesized peptide.
	Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using UBE1L antibody P41847.