中文 
别名:EC 6.3.2.-; Ubiquitin ligase E3 alpha-I;应用:WB
反应种属:Human,Mouse
规格：50μl/100μl
| Description |
|---|
| E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.Kwak K.S., Cancer Res. 64:8193-8198(2004).Dgany O., Am. J. Hum. Genet. 71:1467-1474(2002).Ota T., Nat. Genet. 36:40-45(2004). |
| Specification | |
|---|---|
| Aliases | EC 6.3.2.-; Ubiquitin ligase E3 alpha-I; |
| Entrez GeneID | 197131; |
| Swissprot | Q8IWV7 |
| WB Predicted band size | 36kDa |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human UBR1. |
| Formulation | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Application | |
|---|---|
| WB | 1/500-1/3000 |
 |
Western blot analysis of extracts from Jurkat cells and HepG2 cells, using UBR1 antibody P42397. |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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