Rabbit Polyclonal Antibody to UBR1

包装: 1G|100G|500G|1KG|100KG

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别名:EC 6.3.2.-; Ubiquitin ligase E3 alpha-I;
应用:WB
反应种属:Human,Mouse
规格：50μl/100μl

Description
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.Kwak K.S., Cancer Res. 64:8193-8198(2004).Dgany O., Am. J. Hum. Genet. 71:1467-1474(2002).Ota T., Nat. Genet. 36:40-45(2004).

Description

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.Kwak K.S., Cancer Res. 64:8193-8198(2004).Dgany O., Am. J. Hum. Genet. 71:1467-1474(2002).Ota T., Nat. Genet. 36:40-45(2004).

Specification
Aliases	EC 6.3.2.-; Ubiquitin ligase E3 alpha-I;
Entrez GeneID	197131;
Swissprot	Q8IWV7
WB Predicted band size	36kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Synthesized peptide derived from internal of human UBR1.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.