Rabbit Polyclonal Antibody to UGDH

包装: 1G|100G|500G|1KG|100KG

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别名:UDP-glucose 6-dehydrogenase, UDP-Glc dehydrogenase, UDP-GlcDH, UDPGDH, UGDH
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.

Description

The protein encoded by this gene converts UDP-glucose to
UDP-glucuronate and thereby participates in the biosynthesis of
glycosaminoglycans such as hyaluronan, chondroitin sulfate, and
heparan sulfate. These glycosylated compounds are common components
of the extracellular matrix and likely play roles in signal
transduction, cell migration, and cancer growth and metastasis. The
expression of this gene is up-regulated by transforming growth
factor beta and down-regulated by hypoxia. Alternative splicing
results in multiple transcript variants.

Specification
Aliases	UDP-glucose 6-dehydrogenase, UDP-Glc dehydrogenase, UDP-GlcDH, UDPGDH, UGDH
Entrez GeneID	7358
Swissprot	O60701
WB Predicted band size	55.0kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This UGDH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 465-494 amino acids from the C-terminal region of human UGDH.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500

	UGDH Antibody (C-term) (Cat. #P31118) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the UGDH antibody detected the UGDH protein (arrow).
	UGDH Antibody (C-term) (Cat. #P31118)immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of UGDH Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.