Rabbit Polyclonal Antibody to VDR

包装: 1G|100G|500G|1KG|100KG

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别名:Vitamin D3 receptor, VDR,25-dihydroxyvitamin D3 receptor, Nuclear receptor subfamily 1 group I member 1, VDR, NR1I1
应用:WB,FCM
反应种属:Human
规格：50μl/100μl

Description
This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding the same protein.

Description

This gene encodes the nuclear hormone receptor for vitamin
D3. This receptor also functions as a receptor for the secondary
bile acid lithocholic acid. The receptor belongs to the family of
trans-acting transcriptional regulatory factors and shows sequence
similarity to the steroid and thyroid hormone receptors. Downstream
targets of this nuclear hormone receptor are principally involved
in mineral metabolism though the receptor regulates a variety of
other metabolic pathways, such as those involved in the immune
response and cancer. Mutations in this gene are associated with
type II vitamin D-resistant rickets. A single nucleotide
polymorphism in the initiation codon results in an alternate
translation start site three codons downstream. Alternative
splicing results in multiple transcript variants encoding the same
protein.

Specification
Aliases	Vitamin D3 receptor, VDR,25-dihydroxyvitamin D3 receptor, Nuclear receptor subfamily 1 group I member 1, VDR, NR1I1
Entrez GeneID	7421
Swissprot	P11473
WB Predicted band size	48.3kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This VDR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 274-299 amino acids from the Central region of human VDR.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
FCM	1/10-1/50

	Western blot analysis of lysates from PC-3, LNCaP cell line (from left to right), using VDR Antibody (Center)(Cat. #P32788). P32788 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.
	VDR Antibody (Center) (Cat. #P32788) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.