Rabbit Polyclonal Antibody to Vitamin D3 Receptor (Ab-51)

包装: 1G|100G|500G|1KG|100KG

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别名:1,25-dihydroxyvitamin D3 receptor; NR1I1; vitamin D receptor; vitamin D3 receptor
应用:WB
反应种属:Human,Mouse
规格：50μl/100μl

Description
Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.Baker A.R., Proc. Natl. Acad. Sci. U.S.A. 85:3294-3298(1988).Goto H., Biochim. Biophys. Acta 1132:103-108(1992).Miyamoto K., Mol. Endocrinol. 11:1165-1179(1997).

Description

Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.Baker A.R., Proc. Natl. Acad. Sci. U.S.A. 85:3294-3298(1988).Goto H., Biochim. Biophys. Acta 1132:103-108(1992).Miyamoto K., Mol. Endocrinol. 11:1165-1179(1997).

Specification
Aliases	1,25-dihydroxyvitamin D3 receptor; NR1I1; vitamin D receptor; vitamin D3 receptor
Entrez GeneID	7421;
Swissprot	P11473
WB Predicted band size	40kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Synthesized non-phosphopeptide derived from human Vitamin D3 Receptor around the phosphorylation site of serine 51 (R-R-S(p)-M-K).
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.