Rabbit Polyclonal Antibody to VSIG8

包装: 1G|100G|500G|1KG|100KG

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别名:
应用:WB,IHC
反应种属:Human, Mouse
规格：50μl/100μl

Description
VSIG8 (V-set and immunoglobulin domain-containing protein 8), also known as C1orf204, is a 414 amino acid single-pass type I membrane protein that contains two Ig-like V-type (immunoglobulin-like) domains. VSIG8 exists as two alternatively spliced isoforms and is encoded by a gene mapping to human chromosome 1q23.2. Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. The rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia.

Description

VSIG8 (V-set and immunoglobulin domain-containing protein 8), also known as C1orf204, is a 414 amino acid single-pass type I membrane protein that contains two Ig-like V-type (immunoglobulin-like) domains. VSIG8 exists as two alternatively spliced isoforms and is encoded by a gene mapping to human chromosome 1q23.2. Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. The rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia.

Specification
Swissprot	P0DPA2
WB Predicted band size	44 kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse
Immunogen	Fusion protein of human VSIG8
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Application
WB	1/500-1/2000
IHC	1/200-1/400
ELISA	1/5000-1/10000

	Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse heart tissue and KB cell lysates, Primary antibody: P02002(VSIG8 Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 30 seconds
	The image is immunohistochemistry of paraffin-embedded Human brain tissue using P02002(VSIG8 Antibody) at dilution 1/240. (Original magnification: ×200)
	The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P02002(VSIG8 Antibody) at dilution 1/240. (Original magnification: ×200)