Rabbit Polyclonal Antibody to WWOX (Phospho-Tyr33)

包装: 1G|100G|500G|1KG|100KG

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别名:FOR; WOX1; Aberrant WW domain-containing oxidoreductase;
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. Bednarek A.K., Cancer Res. 60:2140-2145(2000)Ried K., Hum. Mol. Genet. 9:1651-1663(2000)Bednarek A.K., Cancer Res. 61:8068-8073(2001).

Description

WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. Bednarek A.K., Cancer Res. 60:2140-2145(2000)Ried K., Hum. Mol. Genet. 9:1651-1663(2000)Bednarek A.K., Cancer Res. 61:8068-8073(2001).

Specification
Aliases	FOR; WOX1; Aberrant WW domain-containing oxidoreductase;
Entrez GeneID	51741;
Swissprot	Q9NZC7
WB Predicted band size	55kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Peptide sequence around phosphorylation site of tyrosine 33 (W-V-Y(p)-Y-A) derived from Human WWOX.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/1000
IHC	1/50-1/100

	Western blot analysis of extracts from HepG2 cells treated with PMA using WWOX (Phospho-Tyr33) Antibody P40479.The lane on the right is treated with the antigen-specific peptide.
	Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using WWOX (Phospho-Tyr33) antibody P40479 (left)or the same antibody preincubated with blocking peptide (right).