Rabbit Polyclonal Antibody to XPA

包装: 1G|100G|500G|1KG|100KG

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别名:DNA-repair protein complementing XP-A cells; XPAC; Xeroderma pigmentosum group A complementing protein;
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation.Gary W. Daughdrill, Nucleic Acids Res., Jul 2003; 31: 4176 – 4183. Esther M. Hoogervorst, Carcinogenesis, Mar 2003; 24: 613 – 619. Karen M. Vasquez, PNAS, Apr 2002; 99: 5848.

Description

Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation.Gary W. Daughdrill, Nucleic Acids Res., Jul 2003; 31: 4176 – 4183. Esther M. Hoogervorst, Carcinogenesis, Mar 2003; 24: 613 – 619. Karen M. Vasquez, PNAS, Apr 2002; 99: 5848.

Specification
Aliases	DNA-repair protein complementing XP-A cells; XPAC; Xeroderma pigmentosum group A complementing protein;
Entrez GeneID	7507;
Swissprot	P23025
WB Predicted band size	40kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized peptide derived from Internal of human XPA.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000
IHC	1/50-1/100

	Western blot analysis of extracts from COLO205 cells, using XPA antibody P41849.
	Western blot analysis of extracts from COS7 cells (Lane 2), using XPA antiobdy P41849. The lane on the left is treated with systhesized peptide.
	Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using XPA antibody P41849.