Rabbit Polyclonal Antibody to XRCC2

包装: 1G|100G|500G|1KG|100KG

现货支持定制

QQ咨询
| 微信咨询

400-880-2824

满200元免运费
正品保障提供发票
现货闪电当时发货

别名:X-RAY REPAIR; COMPLEMENTING DEFECTIVE; IN CHINESE HAMSTER; 2;
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.JP Scott, Blood, Oct 1981; 58: 665 – 669. G Chevalier, Am. J. Pathol., Jun 1998; 152: 1563. R Williams, J. Biol. Chem., Aug 1993; 268: 18213 – 18217. Michael R. Ladomery, J. Biol. Chem., Dec 1999; 274: 36520.

Description

Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.JP Scott, Blood, Oct 1981; 58: 665 – 669. G Chevalier, Am. J. Pathol., Jun 1998; 152: 1563. R Williams, J. Biol. Chem., Aug 1993; 268: 18213 – 18217. Michael R. Ladomery, J. Biol. Chem., Dec 1999; 274: 36520.

Specification
Aliases	X-RAY REPAIR; COMPLEMENTING DEFECTIVE; IN CHINESE HAMSTER; 2;
Entrez GeneID	7516;
Swissprot	O43543
WB Predicted band size	32kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized peptide derived from internal of human XRCC2.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000
IHC	1/50-1/100

	Western blot analysis of extracts from 293cells, using XRCC2 antibody P41852.
	Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using XRCC2 antibody P41852.