Rabbit Polyclonal Antibody to XRCC3

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别名:DNA-repair protein XRCC3; X-ray repair cross-complementing protein 3;
应用:IHC,ICC
反应种属:Human
规格：50μl/100μl

Description
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C.Liu N., Mol. Cell 1:783-793(1998).Miller K.A., J. Biol. Chem. 277:8406-8411(2002).Liu N., Nucleic Acids Res. 30:1009-1015(2002).

Description

Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C.Liu N., Mol. Cell 1:783-793(1998).Miller K.A., J. Biol. Chem. 277:8406-8411(2002).Liu N., Nucleic Acids Res. 30:1009-1015(2002).

Specification
Aliases	DNA-repair protein XRCC3; X-ray repair cross-complementing protein 3;
Entrez GeneID	7517;
Swissprot	O43542
WB Predicted band size	38kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized peptide derived from internal of human XRCC3.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
IHC	1/50-1/100
ICC	1/100-1/500

	Immunofluorescence analysis of COS-7 cells, using XRCC3 antibody P42215.
	Immunohistochemistry analysis of paraffin-embedded human tonsil tissue using XRCC3 antibody P42215.