Rabbit Polyclonal Antibody to YOD1

包装: 1G|100G|500G|1KG|100KG

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别名:dkfzp451j1719; duba8; otu1; otud2; pro0907
应用:WB
反应种属:Human Rat
规格：50μl/100μl

Description
Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP’s axial channel. Mediates deubiquitination of ‘Lys-27’-, ‘Lys-29’- and ‘Lys-33’-linked polyubiquitin chains. Also able to hydrolyze ‘Lys-11’-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin.Ota T., Nat. Genet. 36:40-45(2004).Gregory S.G., Nature 441:315-321(2006).Mural R.J., Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

Description

Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP’s axial channel. Mediates deubiquitination of ‘Lys-27’-, ‘Lys-29’- and ‘Lys-33’-linked polyubiquitin chains. Also able to hydrolyze ‘Lys-11’-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin.Ota T., Nat. Genet. 36:40-45(2004).Gregory S.G., Nature 441:315-321(2006).Mural R.J., Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

Specification
Aliases	dkfzp451j1719; duba8; otu1; otud2; pro0907
Entrez GeneID	55432;
Swissprot	Q5VVQ6
WB Predicted band size	35kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human Rat
Immunogen	Synthesized peptide derived from internal of human YOD1.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.