Rabbit Polyclonal Antibody to ZGPAT

包装: 1G|100G|500G|1KG|100KG

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别名:ZIP; ZC3H9; GPATC6; GPATCH6; ZC3HDC9; KIAA1847
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
Transcription repressor that specifically binds the 5′-GGAG[GA]A[GA]A-3′ consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis.

Description

Transcription repressor that specifically binds the 5′-GGAG[GA]A[GA]A-3′ consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis.

Specification
Aliases	ZIP; ZC3H9; GPATC6; GPATCH6; ZC3HDC9; KIAA1847
Swissprot	Q8N5A5
WB Predicted band size	57 kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Fusion protein of human ZGPAT
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Application
WB	1/200-1/1000
IHC	1/50-1/300
ELISA	1/5000-1/10000

	Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Human fetal liver tissue, LO2 cell, PC-3 cell, HEPG2 cell lysates, Primary antibody: P09761(ZGPAT Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
	The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P09761(ZGPAT Antibody) at dilution 1/55. (Original magnification: ×200)
	The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P09761(ZGPAT Antibody) at dilution 1/55. (Original magnification: ×200)