Rabbit Polyclonal Antibody to ZIC1/2/3

包装: 1G|100G|500G|1KG|100KG

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别名:Zinc finger protein ZIC 1; Zinc finger protein of the cerebellum 1; ZIC1;
应用:WB,IHC
反应种属:Human,Mouse
规格：50μl/100μl

Description
Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5′-TGGGTGGTC-3′ By similarity.Yokota N., Cancer Res. 56:377-383(1996).

Description

Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5′-TGGGTGGTC-3′ By similarity.Yokota N., Cancer Res. 56:377-383(1996).

Specification
Aliases	Zinc finger protein ZIC 1; Zinc finger protein of the cerebellum 1; ZIC1;
Entrez GeneID	7545;
Swissprot	Q15915
WB Predicted band size	51kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Synthesized peptide derived from internal of human ZIC1/2/3.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000
IHC	1/50-1/100

	Western blot analysis of extracts from Jurkat cells and COLO cells, using ZIC1/2/3 antibody P41873.
	Immunohistochemistry analysis of paraffin-embedded human brain tissue using ZIC1/2/3 antibody P41873.