Rabbit Polyclonal Antibody to ZNF217

包装: 1G|100G|500G|1KG|100KG

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别名:ZABC1
应用:IHC
反应种属:Human
规格：50μl/100μl

Description
ZNF217, also known as ZABC1, is a zinc finger protein belonging to the Kr篓鹿ppel C2H2-type zinc-finger protein family. It localizes to the nucleus and may play a role in transcriptional repression of a variety of genes through the recruitment of co-repressor complexes containing proteins such as CtBP, HDAC1 and HDAC2. In addition, ZNF217 participates in cell differentiation and appears to function as an oncogene. Expression of ZNF217 is amplified in various tumors and overexpression of the protein can attenuate apoptotic signals and lead to epithelial cell immortalization.Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at ‘Ser-473’.

Description

ZNF217, also known as ZABC1, is a zinc finger protein belonging to the Kr篓鹿ppel C2H2-type zinc-finger protein family. It localizes to the nucleus and may play a role in transcriptional repression of a variety of genes through the recruitment of co-repressor complexes containing proteins such as CtBP, HDAC1 and HDAC2. In addition, ZNF217 participates in cell differentiation and appears to function as an oncogene. Expression of ZNF217 is amplified in various tumors and overexpression of the protein can attenuate apoptotic signals and lead to epithelial cell immortalization.Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at ‘Ser-473’.

Specification
Aliases	ZABC1
Entrez GeneID	7764;
Swissprot	O75362
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Fusion protein of human ZNF217
Formulation	Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.