Rabbit Polyclonal Antibody to ZNF354A

包装: 1G|100G|500G|1KG|100KG

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别名:EZNF; HKL1; KID1; KID-1; TCF17; HEL104
应用:IHC
反应种属:Human, Mouse, Rat
规格：50μl/100μl

Description
ZNF354A, also called EZNF, KID-1 or TCF17, belongs to the Krüppel C2H2-type zinc-finger family of proteins that contain KRAB domains and act as transcriptional regulators. Expressed primarily in the adult kidney, ZNF354A is a transcriptional repressor that plays a role in late renal development and is suppressed after renal ischemia. The N-terminus of ZNF354A contains the KRAB domain which confers transcriptional repressor activity, while the C-terminus contains multiple Cys2His2-zinc fingers. ZNF354A is located in the nucleolus and is thought to specifically influence development of the proximal tubule by shutting off dispensable or inhibitory genes. Reduced ZNF354A expression prevents proper cell differentiation and may, therefore, be implicated in renal carcinoma.

Description

ZNF354A, also called EZNF, KID-1 or TCF17, belongs to the Krüppel C2H2-type zinc-finger family of proteins that contain KRAB domains and act as transcriptional regulators. Expressed primarily in the adult kidney, ZNF354A is a transcriptional repressor that plays a role in late renal development and is suppressed after renal ischemia. The N-terminus of ZNF354A contains the KRAB domain which confers transcriptional repressor activity, while the C-terminus contains multiple Cys2His2-zinc fingers. ZNF354A is located in the nucleolus and is thought to specifically influence development of the proximal tubule by shutting off dispensable or inhibitory genes. Reduced ZNF354A expression prevents proper cell differentiation and may, therefore, be implicated in renal carcinoma.

Specification
Aliases	EZNF; HKL1; KID1; KID-1; TCF17; HEL104
Swissprot	O60765
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse, Rat
Immunogen	Fusion protein of human ZNF354A
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Application
IHC	1/30-1/150
ELISA	1/5000-1/10000

	The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P09240(ZNF354A Antibody) at dilution 1/40. (Original magnification: ×200)
	The image is immunohistochemistry of paraffin-embedded Human tonsil tissue using P09240(ZNF354A Antibody) at dilution 1/40. (Original magnification: ×200)